UNITED STATES

SECURITIES AND EXCHANGE COMMISSION

WASHINGTON, D.C. 20549

 

SCHEDULE 13G/A

 

UNDER THE SECURITIES EXCHANGE ACT OF 1934
(Amendment No. 1)*

 

Milestone Pharmaceuticals Inc.

(Name of Issuer)

 

Common Shares, without par value

(Title of Class of Securities)

 

59935V107

(CUSIP Number)

 

March 25, 2020

(Date of Event Which Requires Filing of This Statement)

 

Check the appropriate box to designate the rule pursuant to which this Schedule is filed:

 

  ¨ Rule 13d-1(b)

 

  ¨ Rule 13d-1(c)

 

  x Rule 13d-1(d)

 

* The remainder of this cover page shall be filled out for a reporting person’s initial filing on this form with respect to the subject class of securities, and for any subsequent amendment containing information which would alter the disclosures provided in a prior cover page.

 

The information required in the remainder of this cover page shall not be deemed to be “filed” for the purpose of Section 18 of the Securities Exchange Act of 1934 (“Act”) or otherwise subject to the liabilities of that section of the Act but shall be subject to all other provisions of the Act (however, see the Notes).

 

 

 

 

 

CUSIP No. 59935V107 Page 2 of 15

 

           
1.  

Name of Reporting Persons

 

Venrock Healthcare Capital Partners II, L.P.

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

PN

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

CUSIP No. 59935V107 Page 3 of 15

 

           
1.  

Name of Reporting Persons

 

VHCP Co-Investment Holdings II, LLC

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

OO

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

CUSIP No. 59935V107 Page 4 of 15

 

           
1.  

Name of reporting persons

 

Venrock Healthcare Capital Partners III, L.P.

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

PN

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

 CUSIP No. 59935V107 Page 5 of 15

 

             
1.

Name of reporting persons

 

VHCP Co-Investment Holdings III, LLC

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

OO

                   

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 


CUSIP No. 59935V107
Page 6 of 15

 

             
1.

Name of reporting persons

 

VHCP Management II, LLC

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

OO

                   

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

 CUSIP No. 59935V107 Page 7 of 15

 

           
1.

 

 

Name of reporting persons 

 

VHCP Management III, LLC

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

Delaware

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

OO

                   

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

CUSIP No. 59935V107 Page 8 of 15

 

           
1.  

Name of Reporting Persons

 

Shah, Nimish

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

United States

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

IN

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

CUSIP No. 59935V107 Page 9 of 15

 

           
1.  

Name of Reporting Persons

 

Koh, Bong

2.  

Check the Appropriate Box if a Member of a Group (See Instructions)

(a) x1 (b) ¨

 

3.  

SEC USE ONLY

 

4.  

Citizenship or Place of Organization

 

United States

Number of

Shares

Beneficially

Owned by

Each

Reporting

Person

With:

5.  

Sole Voting Power

 

0

6.  

Shared Voting Power

 

0

7.  

Sole Dispositive Power

 

0

8.  

Shared Dispositive Power

 

0

9.  

Aggregate Amount Beneficially Owned by Each Reporting Person

 

0

10.  

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions) ¨

 

11.  

Percent of Class Represented by Amount in Row (9)

 

0%

12.  

Type of Reporting Person (See Instructions)

 

IN

 

Venrock Healthcare Capital Partners II, L.P., VHCP Co-Investment Holdings II, LLC, Venrock Healthcare Capital Partners III, L.P., VHCP Co-Investment Holdings III, LLC, VHCP Management II, LLC, VHCP Management III, LLC, Nimish Shah and Bong Koh are members of a group for the purposes of this Schedule 13G/A.

 

 

 

 

CUSIP No. 59935V107 Page 10 of 15

 

Introductory Note: This Schedule 13G/A is filed on behalf of Venrock Healthcare Capital Partners II, L.P., a limited partnership organized under the laws of the State of Delaware (“VHCP II LP”), VHCP Co-Investment Holdings II, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Co-Investment II”), Venrock Healthcare Capital Partners III, L.P., a limited partnership organized under the laws of the State of Delaware (“VHCP III LP”), VHCP Co-Investment Holdings III, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Co-Investment III”), VHCP Management II, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Management II”), VHCP Management III, LLC, a limited liability company organized under the laws of the State of Delaware (“VHCP Management III” and collectively with VHCP II LP, VHCP Co-Investment II, VHCP III LP, VHCP Co-Investment III and VHCP Management II, the “Venrock Entities”), Nimish Shah (“Shah”) and Bong Koh (“Koh”) in respect of Common Shares of Milestone Pharmaceuticals Inc.

 

Item 1.

 

  (a) Name of Issuer

 

Milestone Pharmaceuticals Inc.

 

  (b) Address of Issuer’s Principal Executive Offices

 

1111 Dr. Frederik-Philips Boulevard, Suite 420

Montréal, Québec Canada H4M 2X6

 

Item 2.

 

  (a) Name of Person Filing

 

Venrock Healthcare Capital Partners II, L.P.

VHCP Co-Investment Holdings II, LLC

Venrock Healthcare Capital Partners III, L.P.

VHCP Co-Investment Holdings III, LLC

VHCP Management II, LLC

VHCP Management III, LLC

Nimish Shah

Bong Koh

 

  (b) Address of Principal Business Office or, if none, Residence

 

  New York Office:   Palo Alto Office:  
       
  7 Bryant Park   3340 Hillview Avenue  
  23rd Floor   Palo Alto, CA 94304  
  New York, NY 10018      

 

  (c) Citizenship

 

All of the Venrock Entities were organized in Delaware. The individuals are both United States citizens.

 

  (d) Title of Class of Securities

 

Common Shares, without par value

 

  (e) CUSIP Number

 

 

 

 

 

CUSIP No. 59935V107 Page 11 of 15

 

Item 3. If this statement is filed pursuant to §§240.13d-1(b), or 240.13d-2(b) or (c), check whether the person filing is a:

 

Not applicable

  

Item 4. Ownership

 

  (a) Amount Beneficially Owned as of April 3, 2020:

 

             
  Venrock Healthcare Capital Partners II, L.P.     0    
  VHCP Co-Investment Holdings II, LLC     0    
  Venrock Healthcare Capital Partners III, L.P.     0    
  VHCP Co-Investment Holdings III, LLC     0    
  VHCP Management II, LLC     0    
  VHCP Management III, LLC     0    
  Nimish Shah     0    
  Bong Koh     0    

 

  (b) Percent of Class as of April 3, 2020:

 

  Venrock Healthcare Capital Partners II, L.P.     0%    
  VHCP Co-Investment Holdings II, LLC     0%    
  Venrock Healthcare Capital Partners III, L.P.     0%    
  VHCP Co-Investment Holdings III, LLC     0%    
  VHCP Management II, LLC     0%    
  VHCP Management III, LLC     0%    
  Nimish Shah     0%    
  Bong Koh     0%    

 

  (c) Number of shares as to which the person has, as of April 3, 2020:
     

 

  (i) Sole power to vote or to direct the vote

 

             
  Venrock Healthcare Capital Partners II, L.P.     0    
  VHCP Co-Investment Holdings II, LLC     0    
  Venrock Healthcare Capital Partners III, L.P.     0    
  VHCP Co-Investment Holdings III, LLC     0    
  VHCP Management II, LLC     0    
  VHCP Management III, LLC     0    
  Nimish Shah     0    
  Bong Koh     0    

 

 

 

 

CUSIP No. 59935V107 Page 12 of 15

 

  (ii) Shared power to vote or to direct the vote

 

             
  Venrock Healthcare Capital Partners II, L.P.     0    
  VHCP Co-Investment Holdings II, LLC     0    
  Venrock Healthcare Capital Partners III, L.P.     0    
  VHCP Co-Investment Holdings III, LLC     0    
  VHCP Management II, LLC     0    
  VHCP Management III, LLC     0    
  Nimish Shah     0    
  Bong Koh     0    

 

  (iii) Sole power to dispose or to direct the disposition of

 

             
  Venrock Healthcare Capital Partners II, L.P.     0    
  VHCP Co-Investment Holdings II, LLC     0    
  Venrock Healthcare Capital Partners III, L.P.     0    
  VHCP Co-Investment Holdings III, LLC     0    
  VHCP Management II, LLC     0    
  VHCP Management III, LLC     0    
  Nimish Shah     0    
  Bong Koh     0    

 

  (iv) Shared power to dispose or to direct the disposition of

 

             
  Venrock Healthcare Capital Partners II, L.P.     0    
  VHCP Co-Investment Holdings II, LLC     0    
  Venrock Healthcare Capital Partners III, L.P.     0    
  VHCP Co-Investment Holdings III, LLC     0    
  VHCP Management II, LLC     0    
  VHCP Management III, LLC     0    
  Nimish Shah     0    
  Bong Koh     0    

 

Item 5. Ownership of Five Percent or Less of a Class

 

If this statement is being filed to report the fact that as of the date hereof the reporting person has ceased to be the beneficial owner of more than five percent of the class of securities, check the following x.

 

Item 6. Ownership of More than Five Percent on Behalf of Another Person

 

Not Applicable

 

 

 

 

CUSIP No. 59935V107 Page 13 of 15

 

Item 7. Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company or Control Person.

 

Not Applicable

 

Item 8. Identification and Classification of Members of the Group

 

Not Applicable

 

Item 9. Notice of Dissolution of a Group

 

Not Applicable

 

Item 10. Certification

 

Not Applicable

 

 

 

 

CUSIP No. 59935V107 Page 14 of 15

 

SIGNATURE

 

After reasonable inquiry and to the best of my knowledge and belief, I certify that the information set forth in this statement is true, complete and correct.

 

Dated: April 3, 2020

 

                         
Venrock Healthcare Capital Partners II, L.P.       Venrock Healthcare Capital Partners III, L.P.
         
By:   VHCP Management II, LLC       By:   VHCP Management III, LLC
Its:   General Partner       Its:   General Partner
         
By:   /s/ David L. Stepp       By:   /s/ David L. Stepp
    Name:   David L. Stepp           Name:   David L. Stepp
    Its:   Authorized Signatory           Its:   Authorized Signatory
     
VHCP Co-Investment Holdings II, LLC       VHCP Co-Investment Holdings III, LLC
         
By:   VHCP Management II, LLC       By:   VHCP Management III, LLC
Its:   Manager       Its:   Manager
         
By:   /s/ David L. Stepp       By:   /s/ David L. Stepp
    Name:   David L. Stepp           Name:   David L. Stepp
    Its:   Authorized Signatory           Its:   Authorized Signatory
     
VHCP Management II, LLC       VHCP Management III, LLC
         
By:   /s/ David L. Stepp       By:   /s/ David L. Stepp
    Name:   David L. Stepp           Name:   David L. Stepp
    Its:   Authorized Signatory           Its:   Authorized Signatory
     
Nimish Shah       Bong Koh
         
By:   /s/ David L. Stepp       By:   /s/ David L. Stepp
    David L. Stepp, as attorney-in-fact           David L. Stepp, as attorney-in-fact

 

 

 

 

CUSIP No. 59935V107 Page 15 of 15

 

EXHIBITS

 

A: Joint Filing Agreement (incorporated by reference to Exhibit A to Schedule 13G filed February 14, 2020)

 

B: Power of Attorney for Nimish Shah (incorporated by reference to Exhibit B to Schedule 13G filed February 14, 2020)

 

C: Power of Attorney for Bong Koh (incorporated by reference to Exhibit C to Schedule 13G filed February 14, 2020)